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Christopher Lloyd appeared as painter Philip Semenko in the final two episodes of Season 2: Season 2 Episode 21 (I'll be seeing you Part 1) and Season 2 Episode 22 (I'll be seeing you Part 2). Semenko wished to make a painting of Diane Chambers. Diane is thrilled, however Sam is not pleased. Sam threatens to end their relationship if Diane lets Semenko make a painting of her. Initially acquiescing to Sam's request, Diane then lets Semenko make a painting of her. Semenko warns Diane that if she shows Sam the painting, that it will be the end of Sam and Diane's relationship. Diane nevertheless lets Sam know about the painting, and Sam and Diane break up in the Season 2 season finale.

Before Cheers, Lloyd played Reverend Jim Ignatowski from 1978 to 1983 on the TV series Taxi.

Lloyd played Dr. Emmett "Doc" Brown in the "Back to the Future" movie series.

Lloyd's appearance on Cheers was in 1984, one year before he became famous for appearing in Back to the Future (1985). Lloyd also appeared in Back to the Future Part II (1989) and Back to the Future Part III (1990).